Xpose version 4.4.0 released   2012-10-17

Xpose version 4.3.5 released   2012-04-19

Xpose version 4.3.4 released   2012-04-14

Xpose package xpose4generic version 4.3.3 released   2011-01-21
A new version of the package xpose4generic has been released.

Xpose version 4.3.2 released   2010-11-30
A new version of Xpose has been released.

Xpose version 4.3.0 released   2010-10-23 16:46 - Xpose
A new version of Xpose has been released. Lots of new plots and features. Note that, installation of Xpose has been simplified; it is now available through the Comprehensive R Archive Network (CRAN). See for more details.
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Xpose 4.2.1 released   2010-05-26 10:04 - Xpose
* Changed the behaviour of xpose.multiple.plot.default. Now
multiple plots are returned as objects just like single plots are
(no automatic printing from the function that created the plot
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Xpose 4.1.0 released   2009-11-29 12:05 - Xpose
We have updated xpose for NONMEM 7 as well as added functions for odd type (categorical, TTE, count) plots including VPCs.
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Xpose 4 release 4 available   2008-12-14 12:33 - Xpose
This release makes Xpose 4 compatible with R 2.8.0. We have updated the method for opening graphical devices to be consistent with the new methods used in R version 2.8.0. Other changes are considered minor. Please see the change-log for more information.
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Xpose 4 release 3 available   2008-10-24 10:31 - Xpose
A minor fix. In the previous release, in compute.cwres(), a debugging flag had been left in the file resulting in R going into debugging mode when this function was called. This has been fixed in this release.
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Site news archive »

Overview of Xpose

Xpose is an R-based model building aid for population analysis using NONMEM. It facilitates data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.

Data set checkout includes visualization of the observed variable(s), covariates and plots to reveal errors in the data file.

Model diagnostic plots includes the usual residual plots but also plots to check the validity of assumptions specific to non-linear mixed effects models.

Data exploration is also done by various plots but also includes auxiliary screening analyses such as stepwise generalized additive modeling (GAM) and tree based modeling.

The stability of the GAM results with respect to covariate model selection as well as the impact of influential individuals and certain types of covariate interactions can be explored using a bootstrap re-sampling procedure.

To facilitate documentation, Xpose can produce run summaries and run records. The run records are one page summaries of a run consisting of a combination of goodness of fit plots, parameter estimates and the model file. Run records are tabulated summaries of many runs consisting of user comments, termination messages and objective function values.

A Bestiarium has been to produced to demonstrate what Xpose can do.

For more information you may also take a look at the documention page.


The Xpose development team consists of Andrew Hooker, Mats O. Karlsson and E. Niclas Jonsson. We are based at the Division of Pharmacokinetics and Drug Therapy, within the Department of Pharmaceutical Biosciences at Uppsala University.

Xpose is ©1998-2005 E. Niclas Jonsson & Mats Karlsson. ©2005-2008 Andrew C. Hooker, Justin J. Wilkins, Mats O. Karlsson and E. Niclas Jonsson. ©2009-2012 Andrew C. Hooker, Mats O. Karlsson and E. Niclas Jonsson. All rights reserved. Logo